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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Hepatology. 2019 Mar 22;69(6):2455–2470. doi: 10.1002/hep.30541

FIG. 6.

FIG. 6.

GDNF enhances mitochondrial respiration in rat hepatocytes and primary mouse hepatocytes. Comparison of mitochondrial respiration between VEC RALA255–10G rat hepatocytes (with intact autophagy) and siAtg5 RALA255–10G hepatocytes with defective autophagy (A-C). Plotted are means + SEM. (D) Basal oxygen consumption rates (OCR) of VEC RALA255–10G rat hepatocytes cultured for 3 days in medium with or without GDNF and assayed in assay buffer with or without palmitate (Assay). Plotted are means + SEM (***, P<0.001; *, P<0.05. n = 3). (E and F) Mitochondrial respiration profiles of hepatocytes isolated from control (CNTRL) and GDNF transgenic (Tg) that had been fed on a RD or HFD for 7 days. Plotted are means + SEM (**, P<0.01; *, P<0.05. n = 3).