Table 1.
Cytotoxicity of ergosterol peroxide probes via CTG assay. EC50 value expressed as the mean of three independent experiments.
| Number | MDA-MB-231 EC50 (µM) | SUM149 EC50 (µM) | T-47D EC50 (µM) | HMEC EC50 (µM) | TI(HMEC/SUM149) |
|---|---|---|---|---|---|
| Phosphoramide | >11 | >12 | ND | >10 | >1 |
| Doxorubicin | 1 | 1 | ND | >10 | >11 |
| Taxol | 2 | 0.01 | ND | >10 | >800 |
| Capecitabine | 5 | 5 | ND | 10 | >2 |
| 3 | 18 | 9 | 19 | >20 | >3 |
| 3a | 7 | 5 | 10 | >13 | >3 |
| 3b | 16 | 3 | >20 | >20 | >4 |
| 3c | >20 | 5 | >20 | >20 | >4 |
| 3d | >20 | 10 | >20 | >20 | >2 |
| 3e | 16 | 10 | >20 | >20 | >2 |
| 3f | 9 | 5 | >20 | >20 | >4 |
| 3g | 37 | 5 | >20 | >20 | >4 |
| 3h | 25 | 21 | 17 | >20 | >1 |
| 3i | 33 | 5 | 18 | >20 | >4 |
| 3j | 8 | 4 | 11 | >13 | >4 |
| 3k | 10 | 4 | >10 | >14 | >6 |
| 3l | 20 | 18 | >20 | >20 | >1 |
| 3m | 18 | 2 | 18 | >15 | >6 |
| 3n | 7 | 2 | 16 | >15 | >6 |