Table 1.
Baseline Characteristics
| Characteristics | Total N=28 n (%) or median (range) |
|---|---|
| Demographics | |
| Sex | |
| Male | 15 (54) |
| Female | 13 (46) |
| Race | |
| Black/African American | 1 (4) |
| Asian | 27 (96) |
| Age (years) | 37.2 (22.2 – 61.2) |
| BMI (kg/m2) | 22.4 (18.0 – 28.3) |
| Virology and serology | |
| HBV Genotype | |
| B | 9 (32) |
| C | 18 (64) |
| E | 1 (4) |
| HBeAg (+) | 28 (100) |
| HBV DNA (log10 IU/mL) - Screening | 8.3 (7.4–8.8) |
| HBV DNA (log10 IU/mL) - Baseline | 8.2 (7.2 – 8.8) |
| Quantitative HBeAg (log10 IU/mL) | 3.3 (2.3 – 3.6) |
| Quantitative HBsAg (log10 IU/mL) | 4.7 (4.2 – 5.1) |
| ALT (U/L) - Screening | 21 (9 – 47*) |
| Males | 32 (16 – 47*) |
| Females | 18 (9 – 26) |
| ALT (U/L) - Baseline | 21 (9 – 47) |
| Males | 27 (14 – 47) |
| Females | 15 (9 – 30) |
| AST (U/L) | 20 (15 – 30) |
| FIB-4 | 0.7 (0.4 – 2.3) |
| INR | 1.0 (0.9 – 1.1) |
| Total Bilirubin (mg/dL) | 0.6 (0.3 – 2.0) |
| Albumin (g/dL) | 4.2 (3.5 – 4.8) |
| Platelets (x103/mm3) | 242.5 (137 – 325) |
| White blood cells (x103/mm3) | 5.0 (3.0 – 9.1) |
*
A male participant with ALT 47 was eligible enrolled under the study protocol v6.0 (ALT ≤60 for males, ≤40 for females). The study protocol v7.0 was revised as ALT ≤45 for males, ≤30 for females.