Table 1.
Characteristics of VACS and VACS-BC with Methylation Data
| VACS (n=142,152) | VACS-BC (n=728) | |
|---|---|---|
|
| ||
| Mean Age (SD) | 47.2 (10.9) | 52.8 (7.9) |
|
| ||
| HIV+ | 31% | 84% |
|
| ||
| Male | 97% | 97% |
|
| ||
| Race/Ethnicity | ||
| African-American | 48% | 81% |
| White | 40% | 15% |
| Hispanic/Other | 12% | 4% |
|
| ||
| Marijuana or Hashish Use | - | |
| Never | 26% | |
| Not in Past Year | 45% | |
| <Once per Month | 9% | |
| ≥Once per Month | 14% | |
| Unknown | 6% | |
|
| ||
| Smoking Variables | ||
|
| ||
| Median # Smoking Observation (IQR) | 6 (3–9) | 15 (8–24) |
|
| ||
| Self-Report from EMR | ||
|
| ||
| Most Recent | ||
| Never (0) | 33% | 23% |
| Past (1) | 24% | 24% |
| Current (2) | 43% | 53% |
|
| ||
| Most Common | ||
| Never (0) | 29% | 20% |
| Past (1) | 18% | 12% |
| Current (2) | 53% | 68% |
|
| ||
| Trajectory | ||
| Mostly Never (0) | 24% | 14% |
| Mix (1) | 26% | 22% |
| Current & Past (2) | 16% | 26% |
| Mostly Current (3) | 33% | 37% |
|
| ||
| Current Smoking Based on Methylation Markers | ||
|
| ||
| Cg05575921<0.80 | 69% | |
|
| ||
| Cg05575921<0.70 | 54% | |
|
| ||
| Cg03636183<0.68 | 82% | |
|
| ||
| Cg03636183<0.59 | - | 52% |
VACS: Veterans Aging Cohort Study
VACS-BC: Veterans Aging Cohort Study - Biomarker Cohort Substudy
EMR: Electronic Medical Record