. Author manuscript; available in PMC: 2020 May 27.

Published in final edited form as: J Psychopharmacol. 2018 Nov 29;33(1):12–24. doi: 10.1177/0269881118812095

Table 4.

Distribution of (2R,6R)-hydroxynorketamine (HNK) in the plasma and brain of rats.

	C_max (μg/mL)		AUC₀→∞ (μg/mL×h)		t_1/2 (h)		BA (%)
	p.o.	i.v.	p.o.	i.v,.	p.o.	i.v.	BA (%)
Plasma	1.50	9.56^a	2.65	6.27	6.9	8.0	42
Brain	1.52	9.13^a	2.58	6.09	5.7	8.8	ND

AUC: area under the curve; BA: bioavailability; C_max: maximum concentration; i.v.: intravenous; ND: not determined; p.o.: oral; t_1/2: half-life.

Parameters calculated from eight sampling timepoints following a single dose of 10 mg/kg (free drug dose).

Concentrations measured five minutes after i.v. dosing; values not representative of actual peak.