Table 2.

Demographic and clinicopathological features of CT negative MTC patients

	Author	Gender	Age (years)	Size (mm)	Histology	CT-HIC	CT	Assay	Upper reference limit
1	Sobol	F	82	20	WDMTC	Negative	Normal limits	NA	NA
2	Schmid 1	M	28	NA	WDMTC	Weak	NA	Immunotech	NA
3	Schmid 2	M	46	NA	WDMTC	Weak	NA	Immunotech	NA
4	Schmid 3	F	45	NA	WDMTC	Weak	NA	Immunotech	NA
5	Schmid 4	M	37	NA	WDMTC	Negative	NA	Immunotech	NA
6	Redding	F	31	45	WDMTC	Diffuse	28	RIA	< 150
7	Bockhorn	F	50	20	PDMTC	Weak	0.8	Nichols	< 4.6
8	Sand	F	73	NA	PDMTC	Weak	5.3	Nichols	< 10
9	Dora	M	43	20	PDMTC	Diffuse	4	Immunolite	< 12
10	Wang	M	68	70	WDMTC	Weak	38	NA	< 10
11	Giovanella	F	43	48	WDMTC	Diffuse	4.7	Immunolite	< 10
12	Alapat	F	16	30	WDMTC	Diffuse	4	Immunolite	< 4.6
13	Chernyavsky	F	40	20	WDMTC	Negative	2.1	Ventana Medical System Inc.	< 5.0
14	Nakazawa	M	76	60	WDMTC	Weak	22	NA	< 10
15	Frank-Raue 1	F	61	10	WDMTC	Weak	2.9	Nichols	< 10
16	Frank-Raue 2	M	70	80	WDMTC	Weak	< 2	DiaSorin	< 6.1 male < 3.6 female
17	Frank-Raue 3	F	50	20	WDMTC	Weak	0.8	Nichols	< 10
18	Frank-Raue 4	M	47	30	PDMTC	Focal	2.6	Immunolite	< 8.4 male < 5 female
19	Frank-Raue 5	F	53	45	WDMTC	Diffuse	NA	NA	NA
20	Frank-Raue 6	M	45	18	PDMTC	Weak	11	Non commercial	< 18
21	Frank-Raue 7	F	45	55	PDMTC	Focal	1.5	CIS	< 10
22	Ismi	NA	57	NA	PDMTC	Negative	5.6	NA	< 10
23	Brutsaert	F	49	26	WDMTC	Diffuse	< 2	NA	< 6
24	Kim	M	34	10	PDMTC	Negative	3.7	NA	< 10
25	Kasajima	F	48	30	WDMTC	Negative	29	NA	NA
26	Samà 1	M	60	38	NA	Focal	7.8	NA	NA
27	Samà 2	F	66	NA	NA	NA	5	NA	NA
28	Samà 3	M	53	12	NA	Negative	< 10	NA	NA
29	Samà 4	M	62	45	NA	Focal	13	NA	NA
30	Parmer	F	74	20	WDMTC	Negative	Normal limits	NA	NA
31–49	Zhou	11 M 8 F	≥30 3 cases; < 30 16 cases	≤10mmm 14 cases > 10 mm 5 cases	NA	Positive in 8 cases Negative in 11 cases	NA	NA	NA

(F female, M male, WDMTC well differentiated MTC, PDMTC poorly differentiated MTC, CT calcitonin, CT-IHC immunohistochemistry for CT, NA Not Avaible)