Table 4.
Intraoperative and postoperative findings
| Author | Surgery | Tumor grading | Follow-up | Recurrence | CT-IHC | CGRP-IHC | CgA-IHC | Syn-IHC | TG-IHC | CEA-IHC | RET mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sobol | TT | WDMTC | 6 month | Lymph nodes, liver and bone | – | – | + | NA | NA | + | NA |
| Schmid 1 | NA | WDMTC | NA | NA | NA | + | + | NA | – | – | NA |
| Schmid 2 | NA | WDMTC | 19 month | Lymph nodes | NA | + | + | NA | – | – | NA |
| Schmid 3 | NA | WDMTC | NA | NA | NA | – | + | NA | – | – | NA |
| Schmid 4 | NA | WDMTC | NA | NA | NA | – | + | NA | NA | – | NA |
| Redding | TT + LYA | WDMTC | 43 month | Negative | + | NA | NA | + | NA | + | – |
| Bockhorn | TT + LYA | PDMTC | NA | NA | NA | NA | + | NA | – | + | + |
| Sand | TT + LYA | PDMTC | Deceased 6 weeks | NA | NA | NA | NA | NA | NA | NA | NA |
| Dora | TT | PDMTC | NA | NA | + | NA | + | + | – | NA | – |
| Wang | NA | WDMTC | 12 months | Negative | + | NA | + | NA | – | + | NA |
| Giovanella | TT + LYA | WDMTC | 24 months | NA | + | NA | NA | NA | NA | NA | NA |
| Alapat | TT + LYA | WDMTC | 20 months | Negative | + | NA | + | NA | – | + | NA |
| Chernyavsky | TT + LYA | WDMTC | 12 months | Negative | – | NA | + | + | + | NA | + |
| Nakazawa | TT | WDMTC | 18 months | Negative | NA | NA | + | + | – | NA | NA |
| Frank-Raue 1 | ET | WDMTC | 72 months | Negative | + | NA | + | + | – | + | – |
| Frank-Raue 2 | NA | WDMTC | 25 months | Pulmonary | + | NA | + | + | – | + | – |
| Frank-Raue 3 | NA | WDMTC | 150 months | Lymph modes | + | NA | + | + | – | + | + |
| Frank-Raue 4 | NA | PDMTC | 18 months | Local tumor infiltration | + | NA | + | + | – | + | – |
| Frank-Raue 5 | NA | WDMTC | 21 months | Lymph node, bone, brain | + | NA | + | + | – | + | + |
| Frank-Raue 6 | NA | PDMTC | 21 months | Pulmonary | + | NA | + | + | – | + | + |
| Frank-Raue 7 | NA | PDMTC | 36 months | Dead because of pulmonary failure | + | NA | + | + | – | + | + |
| Ismi | NA | PDMTC | NA | NA | – | NA | + | + | – | NA | NA |
| Brutsaert | TT + LYA | WDMTC | NA | NA | NA | NA | NA | NA | NA | NA | + |
| Kim | ET | PDMTC | 12 months | Negative | – | NA | + | + | + | – | – |
| Kasajima | NA | WDMTC | NA | NA | NA | + | + | + | NA | NA | – |
| Samà 1 | TT | NA | 120 months | Negative | + | NA | + | NA | NA | + | – |
| Samà 2 | NA | NA | 120 months | Negative | NA | NA | NA | NA | NA | NA | NA |
| Samà 3 | NA | NA | 36 months | Negative | – | NA | – | NA | NA | – | + |
| Samà 4 | NA | NA | 36 months | Negative | + | NA | + | NA | NA | – | – |
| Parmer | TT | WDMTC | NA | NA | – | NA | + | + | – | + | NA |
| Zhou | NA | NA | NA | NA |
+ 8 cases - 11 cases |
NA |
+ 18 cases - 1 case |
+ 19 cases |
+ 5 cases - 14 cases |
+ 4 cases - 15 cases |
NA in 15 cases - In 4 cases |
(TT, total thyroidectomy; ET, emithyroidectomy; LYA, lymphadenectomy; WDMTC, well differentiated MTC; PDMTC, poorly differentiated MTC; NA, not avaible; −, negative; +, positive; IHC, immunohistochemistry; CT, calcitonin; CEA, Carcinoembryonic antigen; CGRP, calcitonin gene related peptide; CgA, chromogranin A; Syn, synaptofisine; TG, thyroglobulin)