Table 5.
Definitive pathology examination and immunohistochemistry
| Authors | Cell morphological characteristics | Neuroendocrine tumor structure | Amyloid substance | Lymph node metastasis | Thyroid capsular invasion | Vascular tumor thrombus |
|---|---|---|---|---|---|---|
| Sobol | Ovoid-to-spindle-shaped in groups divided by fibrous septum | Neurosecretory granules | Focal | NA | NA | NA |
| Schmid 1 | Polygonal and spindle cells | NA | NA | NA | Negative | Negative |
| Schmid 2 | Polygonal and spindle cells | NA | NA | NA | Negative | Negative |
| Schmid 3 | Polygonal and spindle cells | NA | NA | NA | Positive | Positive |
| Schmid 4 | Polygonal and spindle cells | NA | NA | NA | Positive | Positive |
| Redding | Nets of fairly uniform cells | NA | NA | NA | Negative | NA |
| Bockhorn | Polyhedral and spindle cells | Positive | NA | NA | Negative | NA |
| Sand | NA | NA | NA | Positive | Positive | Positive |
| Dora | Spindle-shaped celss | NA | Positive | Positive | Positive | Positive |
| Wang | NA | NA | Negative | Positive | Positive | Positive |
| Giovanella | Elongated cells | NA | NA | NA | NA | NA |
| Alapat | Spindle-round-polygonal cells | NA | NA | Positive | Positive | Positive |
| Chernyavsky | Fairly uniform round and polygonal cells | Positive | NA | Negative | Negative | Negative |
| Nakazawa | “Zellballen” pattern | NA | NA | Negative | Negative | Negative |
| Frank-Raue 1 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 2 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 3 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 4 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 5 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 6 | NA | NA | NA | NA | NA | NA |
| Frank-Raue 7 | NA | NA | NA | NA | NA | NA |
| Ismi | Atypical cells | Positive | NA | NA | NA | NA |
| Brutsaert | NA | NA | NA | Negative | Positive | Negative |
| Kim | NA | Positive | NA | Negative | Negative | Negative |
| Kasajima | Polygonal-spindle-shaped cells | Positive | NA | Negative | Negative | Negative |
| Samà 1 | Small-spindle cells | Positive | Positive | NA | NA | NA |
| Samà 2 | NA | NA | NA | NA | NA | NA |
| Samà 3 | NA | NA | NA | NA | NA | NA |
| Samà 4 | NA | NA | NA | NA | NA | NA |
| Parmer | Spindle-round cells | NA | Negative | NA | NA | NA |
| Zhou |
Polygonal cells in 17 cases Spindle cells in 2 cases |
Positive in 16 cases Negative in 3 cases |
Positive in 11 cases Negative in 8 cases |
Positive in 3 cases Negative in 16 cases |
Positive in 8 cases Negative in 11 cases |
Positive in 1 case Negative in 18 cases |
(NA not avaible)