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. 2019 May 29;9:8051. doi: 10.1038/s41598-019-44537-0

Figure 2.

Figure 2

Transition to formative pluripotency is coupled to a reduction in CC-L, G1-L and SG2M-L. (A) Left panel, density distribution of single cell CC-L comparing cells maintained in the naive ground state and during the transition to formative pluripotency. Statistical differences between groups were assessed by a Mann Whitney U test. Center and right panels, plots showing time of birth vs. CC-L for 2i + LIF and Diff treated cells, respectively. Generation numbers for the different cells is shown in colors. Dashed lines show the limit of observable events. (B,C) Same as in (A) but for G1-L and SG2M-L. N = 516 and 623 cells for naive ground state and differentiation, respectively.