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. 2019 May 29;9:7995. doi: 10.1038/s41598-019-44475-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of CoQ₁₀ on oxidative stress and apoptosis in pancreatic islets and sera during Tac-induced DM in rats. Representative images and quantification of immunohistochemistry for 8-OHdG (a–d,m) and 4-HHE (e–h,o) and TUNEL assays (i–l,p) using tissue sections from rats. (n) Serum 8-OHdG excretion. Arrowheads indicate 8-OHdG-, 4-HHE-, and TUNEL-positive cells. Scale bar = 50 µm (all panels). Data are presented as the mean ± SE (n = 8). One-way ANOVA was used to analyze the data. ^&P < 0.05 versus the Vh group; ^$P < 0.05 versus the CoQ₁₀ groups; ^#P < 0.05 versus the Tac group.