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. 2019 May 29;9:7995. doi: 10.1038/s41598-019-44475-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transmission electron microscopy. (a) Mitochondrial ultrastructure in pancreatic beta cells. White asterisks indicate mitochondria. Arrowheads indicate insulin granules. Scale bar = 0.5 µm (panels in a). (b–d) Quantitative analysis of mitochondrial area and number of insulin granules in the experimental groups. (e–g) Three-dimensional (3D) reconstruction of mitochondria in isolated islets treated with drugs. (e) Representative 3D reconstruction of mitochondria, revealing mitochondrial morphology. The reconstruction was based on a series of about 20 sections cut using an ultramicrotome. Scale bar = 200 nm (panels in e). Quantitative analysis of mitochondrial volume (f) and surface area (g). Data are presented as the mean ± SE (n = 8). One-way ANOVA was used to analyze the data. ^&P < 0.05 versus the Vh group; ^$P < 0.05 versus the CoQ₁₀ groups; ^#P < 0.05 versus the Tac group.