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. 2019 May 29;9:8025. doi: 10.1038/s41598-019-44485-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver Health Biomarker Measurement in Blood Serum. (A) Analysis of the liver enzyme Alanine Aminotransferase (ALT), also known as serum glutamate-pyruvate transaminase (SGPT) was done in the blood serum of the mice showed an increase in the disease control animals (DC) indicating the onset of liver damage as compared to the normal control animals (NC). Treatment of the diseased animals with Methotrexate (MTX) and Ashwashila (ASHW) showed a significant reduction in the levels of ALT post-treatment. (B) Analysis of the Aspartate Aminotransferase (AST) also known as serum glutamic-oxaloacetic transaminase (SGOT) enzyme showed a substantial increase in the disease control animals as compared to the healthy control animals. MTX Treatment showed a considerable decrease in the liver toxicity as compared to the DC animals; ASHW treatment showed a minor reduction in the AST levels as compared to the DC animals. Values in the results are Mean ± SEM. A one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison t-test was used to calculate the statistical difference. Student unpaired t-test was used to calculate the statistical difference in comparison to MTX (p-value ## and ** ≤ 0.01).