Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 29;9:8016. doi: 10.1038/s41598-019-44387-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Hypoplastic kidneys of SALL1-KO founder foetuses. Foetuses developed from zygotes injected with Platinum TALENs were obtained at day 36–37 of gestation. Left panels: Kidney tissue of a SALL1 heterozygous founder foetus (M231-8; WT/13 bp del). Middle and right panels: Kidney tissue of two homozygous SALL1-KO founder foetuses (M230-1 and M231-6; 5 bp/13 bp del and 1 bp/5 bp del). The homozygous KO foetuses showed severe renal hypoplasia. The signals for SALL1 and WT1 were markedly reduced in the rudimentary kidney tissue of the foetuses with homozygous KO mutations. Scale bars: 500 μm.