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. 2019 May 29;9:8016. doi: 10.1038/s41598-019-44387-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anephrogenic phenotype in F1 progeny carrying SALL1 mutations. F1 foetuses on day 40 of gestation were obtained by mating founder SALL1 mutant pigs. All foetuses with homozygous mutations (lower panels; W307-6, W307-7, W307-8, W307-9, and W307-11) exhibited various phenotypes of renal hypoplasia. Foetuses with heterozygous mutations (upper panels; W307-1, W307-2, W307-4, and W307-10) showed normally formed kidneys like those of a WT foetus (W307-3). Scale bars (white): 2 mm.