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. 2019 May 29;9:8002. doi: 10.1038/s41598-019-44513-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pulmonary tuberculosis patients from both India and China exhibit substantial molecular degree of perturbation. (A,B) Left panels: Histograms show the single sample molecular degree of perturbation (MDP) score values relative to the healthy control group for each country (pulmonary TB: PTB, healthy controls: HC). MDP values were calculated as described in Methods. Right panels: Scatter plots of the summary data for each country are shown. MDP score values were compared between PTB patients (C) or healthy controls (D) from India or China. Lines in the scatter plots represent median values. Data were compared using the Mann–Whitney U test.