Schematic representation of structural characteristics of KIR proteins (a) and typical KIR A and B genotypes (b). ITIM, immunoreceptor tyrosine-based inhibition motifs; DAP12, an activating adaptor protein; ITAM, immunoreceptor tyrosine-based activating motifs; FcεRIγ, an accessory protein; C1/C2, HLA-C alleles bearing C1 or C2 epitopes