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KIR involvement in miscarriage depends on the expression and polymorphism of the classical and nonclassical HLA class I molecules. The HLA-C2 allele is associated with miscarriage when KIR AA genotype is present in uNKs but not when the genotype is AB or BB. KIR2DL4-mediated inhibition of uNKs depends on HLA-G expression in the EVT, described as associated with polymorphisms, especially a 14-bp insertion/deletion polymorphism in exon 8 (adapted from Moffett et al. [57])
