Table 4.

Genotype distribution and allele frequencies of the VEGF -2549 I/D polymorphism in control and case group

Genotype	Fetus		Mother		Father
VEGF -2549 I/D	Controls N = 100 (%)	Cases N = 100 (%)	Controls N = 100 (%)	Cases N = 100 (%)	Controls N = 100 (%)	Cases N = 100 (%)
II	62 (62%)	27 (27%)	18 (18%)	10 (10%)	29 (29%)	17 (17%)
ID	30 (30%)	50 (50%)	72 (72%)	75 (75%)	66 (66%)	75 (75%)
DD	8 (8%)	23 (23%)	10 (10%)	15 (15%)	5 (5%)	8 (8%)
I	154 (0.77)	104 (0.52)	108 (0.54)	94 (0.47)	124 (0.62)	110 (0.55)
D	46 (0.23)	96 (0.48)	92 (0.46)	106 (0.53)	76 (0.38)	90 (0.45)
HWE p value	2.34 0.12	0 1.00	20.18 < 0.00001**	25.38 < 0.00001**	16.05 0.00009**	26.24 < 0.00001**
	OR (95%CI)	p value	OR (95%CI)	p value	OR (95%CI)	p value
ID Vs II	3.82 (2.01–7.25)	< 0.001**	1.87 (0.81–4.33)	0.13	0.93 (0.97–3.84)	0.11
DD Vs II	6.60 (2.62–16.61)	< 0.001**	2.7 (0.88–8.21)	0.07	2.72 (0.76–9.69)	0.11
ID + DD Vs II	4.41 (2.42–8.02)	< 0.001**	1.97 (0.86–4.52)	0.10	1.99 (1.01–3.92)	0.04*
DD Vs II+ ID	0.29 (0.12–0.68)	0.003*	0.63 (0.26–1.47)	0.43	0.60 (0.19–1.91)	0.38
ID Vs II + DD	2.33 (1.26–4.30)	0.009*	1.16 (0.59–2.27)	0.77	1.54 (0.45–5.24)	0.70
D Vs I	3.09 (2.00–4.75)	< 0.001**	1.29 (0.87–1.92)	0.19	1.36 (0.91–2.02)	0.12

p value < 0.05* is statistically significant, p value < 0.001**