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. 2019 Mar 11;95(3):111–135. doi: 10.2183/pjab.95.010

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© 2019 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Gallery of protein structures of VGICs and VSP (taken from ref. 157). K_v1.2–K_v2.1 chimera: human voltage-gated potassium channel (PDB ID: 2R9R), TPC1: plant two-pore cation channel (PDB ID: 5E1J), Ca_v1.1: human skeletal muscle-type voltage-gated calcium channel (PDB ID: 5GJV), Na_vPaS: insect voltage-gated sodium channel (PDB ID: 5X0M), HCN1: human hyperpolarization-activated cyclic nucleotide-gated channel (PDB ID: 5U6O), Slo1: large conductance calcium-activated voltage-gated potassium channel from Aplysia (PDB ID: 5TJ6), Ci-VSP: sea squirt voltage-sensing phosphatase (full length model based on coordinates from PDB ID: 3AWF and PDB ID: 4G7V), mH_v1cc: mouse voltage-gated proton channel in a chimeric form containing part of S2–S3 from Ci-VSP and the coiled coil structure of GCN4 (dimer model based on coordinates from PDB ID: 3WKV). Na_vPaS, K_v1.2–K_v2.1 chimera and Slo1 have four VSDs within a tetramer. TPC1 has four VSDs within a dimer. Ci-VSP has a single VSD. mH_v1cc has two VSDs within a dimer.