Figure 1.

A schematic diagram of the pCaSR gene exon/intron and protein domains. Exons were drawn to the scale, but introns were not. (A) There are seven exons and six introns in the DNA of the pCaSR gene. Blank bars (part of exon 2 and 7) represent exons which are not involved in mRNA translation and gray bars represent mRNA coding regions including part of exon 2, exons 3 to 6 and part of exon 7). ATG, initiation codon; TAA, stop codon. (B) pCaSR protein contains 1,079 AA residues. Open arrowhead: additional 10 AA which is associated with alternative splicing. SP, signal peptide; VFT, venus flytrap domain; Cys, cysteine rich domain; ECD, extracellular domain; TMD, transmembrane domain; ICD, intracellular domain.