Table 4.

Multivariable-adjusted^* Cox model adjusted for decade of life^†: Risk of CVD onset in smokers compared to nonsmokers during 12-year follow-up after examinations 1, 3, and 6 in Framingham offspring study participants

	Examination 1 (1971–1982)				Examination 3 (1983–1994)				Examination 6 (1995–2006)
Sex	N	HR	CI	P-value	N	HR	CI	P-value	N	HR	CI	P-value
Women	902	1.7	1.0–2.7	0.034	1375	1.5	0.9–2.3	0.084	1432	1.6	1.0–2.4	0.038
Men	907	2.1	1.5–2.9	<0.0001	1273	2.0	1.5–2.7	<0.0001	1161	2.1	1.4–3.0	<0.0001

CVD = cardiovascular disease; HR = hazard ratio; CI = 95% confidence interval.

^*Multivariable-adjusted Cox model adjusted for systolic blood pressure, diastolic blood pressure, total cholesterol to high-density lipoprotein ratio, body mass index, log of triglyceride levels, diabetes, treatment for hypertension, treatment for elevated cholesterol.

^†Decade of life: age grouped by decade at start of 12-year follow-up period following examinations 1, 3, and 6 as categorical variable (40–49 years: reference group, 50–59 years, and 60–69 years).