Table 3.

Studies of prevalence of adrenal insufficiency in patients with bilateral adrenal metastases.

Prevalence of AI as documented by ACTH stimulation test
Cedermark et al [28]	1981	0/4 (0%)
Seidenwurm et al [29]	1984	2/57 (3.5%)
Redman et al [30],∗	1987	5/15 (33.3%)
Lutz et al [31],∗∗	2000	0/9 (0%)
Total prevalence of AI			7/85 (8.2%)
Total prevalence of AI excluding Redman et al[30],*			2/70 (2.9%)
Prevalence of AI as documented by either ACTH stimulation test or clinical criteria
Cedermark et al [28]	1981	0/4 (0%)
Seidenwurm et al [29]	1984	5/57 (8.7%)
Redman et al [30],∗	1987	5/15 (33.3%)
Lutz et al [31],∗∗	2000	0/9 (0%)
Lam et al [32]	2002	4/229 (1.74%)
Delivanis et al [13]	2016	2/50 (4%)
Total prevalence of AI			16/264 (6.1%)

^∗All cases had a basal cortisol level of >300 nmol/L but failed mount an appropriate response to ACTH stimulation.

^∗∗Lutz et al - study only contained subjects with subclinical AI rather than overt AI.