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Loading increases FGF21 levels in serum and hepatic FGF21 mRNA. Effects of increased loading in WT male mice on (A) serum levels of FGF15; (B) serum levels of FGF21; (C) mRNA levels of FGF21/18S in liver, WAT, cortical bone (Cort. Bone), and skeletal muscle (Sk. Muscle); and (D) serum levels of cytokines, 6 days after implantation of control or load capsules. Data are expressed as means ± SEM. *P < 0.05; **P < 0.01. n.d., not detectable; WT, wild-type.
