Table 1.

The main features of included studies.

Author	Year	Disease	Country	Region	Genotyping methods	Number of Cases	Number of controls	Characteristics of controls	Polymorphisms	NOS score
Chatzikyriakidou A	2010	RA	Greece	Europe	PCR–RFLP	136	147	Healthy	rs2910164(miRNA-146)	6
Yang XK	2016	RA	China	Asia	TaqMan	386	576	Healthy	rs3746444(miRNA-499)	7
Singh S	2014	JIA-ERA	India	Asia	PCR–RFLP	150	216	Healthy	rs2910164(miRNA-146)	7
El-Shal AS	2013	RA	Egypt	Middle East	PCR–RFLP	217	245	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499)	6
Shaker OG	2018	RA	Egypt	Middle East	TaqMan	104	112	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499)	7
Hashemi M	2012	RA	Iran	Middle East	T-ARMS-PCR	104	110	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499)	6
Yang B	2010	RA	China	Asia	PCR–RFLP	208	240	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499)	7
Aleman-Avila I	2017	RA	Mexico	North America	TaqMan	412	486	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499), rs11614913(miRNA-196)	7
Zhou X	2015	RA	China	Asia	NA	598	821	NA	rs2910164(miRNA-146)	5
Hassine HB	2017	RA	Tunisia	Middle East	PCR–RFLP	165	150	Healthy	rs2910164(miRNA-146)	6
Maharaj AB(1)	2018	PsA	South Africa	Africa	PCR–RFLP	84	62	Healthy	rs2910164(miRNA-146)	6
Maharaj AB(2)	2018	PsA	South Africa	Africa	PCR–RFLP	32	38	Healthy	rs2910164(miRNA-146)	6
Jimenez-Morales S	2012	JRA	Mexico	North America	TaqMan	210	531	Healthy	rs2910164(miRNA-146)	7
Ciccacci C	2016	RA	Italy	Europe	TaqMan	192	298	Healthy	rs2910164(miRNA-146)	7
Ayeldeen G	2018	RA	Egypt	Middle East	real-time PCR	52	56	Healthy	rs2910164(miRNA-146), rs3746444(miRNA-499)	6
Toraih EA	2016	RA	Egypt	Middle East	TaqMan	95	200	Healthy	rs3746444(miRNA-499), rs11614913(miRNA-196)	6
Fattah SA	2018	RA	Egypt	Middle East	PCR–RFLP	100	100	Healthy	rs3746444(miRNA-499)	6
Bogunia-Kubik K	2016	RA	Poland	Europe	PCR–RFLP	111	130	Healthy	rs2910164(miRNA-146)	6
Chatzikyriakidou A	2010	PsA	Greece	Europe	PCR–RFLP	29	66	NA	rs2910164(miRNA-146)	6

HWE: Hardy–Weinberg equilibrium; NOS: Newcastle-Ottawa Quality Assessment Scale.