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. 2019 May 16;2019:7329131. doi: 10.1155/2019/7329131

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Copyright © 2019 You Wu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mdivi-1 reestablished the mitochondrial fusion-fission balance in the CLP mice. Mice were pretreated with Mdivi-1 (20 mg/kg) before undergoing CLP surgery and were sacrificed at 24 h after CLP surgery. (a) Western blot assay and quantitative analysis of mitochondrial and cytosolic MFN2, OPA1, and Drp1 expression. (b) Western blot assay and quantitative analysis of p-Drp1 expression. (c) Micrographs of mitochondria observed using a transmission electron microscopy and quantitative analysis of the average mitochondrial area in five CD4⁺ T cells (magnification: 10000x). Scale bars, 0.5 μm. The results are shown as the mean ± SD; n = 5. ^∗ P < 0.05 vs. the sham group (^∗∗ P < 0.01, ^∗∗∗ P < 0.001); ^& P < 0.05 vs. the CLP group (^&& P < 0.01, ^&&& P < 0.001).