. 2019 May 29;14:118. doi: 10.1186/s13023-019-1080-y

Table 12.

Guidance statements for cardiac valve replacement, left ventricular apical aneurysms and tracheostomy

Statement	Percentage consensus
Cardiac (aortic, mitral) valve replacement should be considered in patients with MPS VI who display symptomatic and severe valve stenosis or regurgitation Evidence Grade: C (level 4 studies)	100%
Left ventricular apical aneurysms occur rarely in patients with MPS VI, but should be resected whenever possible Evidence Grade: D (limited published evidence)	85%

Statement

Percentage consensus

Cardiac (aortic, mitral) valve replacement should be considered in patients with MPS VI who display symptomatic and severe valve stenosis or regurgitation

Evidence Grade: C (level 4 studies)

100%

Left ventricular apical aneurysms occur rarely in patients with MPS VI, but should be resected whenever possible

Evidence Grade: D (limited published evidence)

85%