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. 2019 May 29;20:106. doi: 10.1186/s12931-019-1071-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The knockdown of TM4SF1 suppressed colony formation and cell invasion and migration in A549 and H1299 cell lines. a RT-PCR and western blots confirmed the silencing of TM4SF1 in A549 and H1299 cell lines. b The silencing of TM4SF1 by siRNA inhibited colony formation in A549 and H1299 cell lines (left panel). Right panel showed quantitative analysis of colony formation. The numbers of colonies in NC cells were set to 100%. Values are expressed as the mean ± SD from three independent experiments, and the asterisk indicates the statistical significance compared to the controls (***, p < 0.001). c Cell migration and invasion assay in NC and TM4SF1 silenced A549 and H1299 cell lines by a 24-transwell system. Original magnification× 10, Asterisks indicate a significant level of proliferation compared with controls (***, p < 0.001), the right panel indicates the quantitative analysis of transwell cell invasion and migration assay