Table 1.
Baseline characteristics of 82 patients diagnosed with IC in the ICU
| N (%) or P50 (P25,P75) | Mortality status (all-cause) | ||||
|---|---|---|---|---|---|
| Survived (n = 40) | Did not survive (n = 42) | Z/χ2/ Fisher’s exact test | P | ||
| Age (years) | 76.0 (65.8, 82.0) | 76.0 (61.3, 81.8) | 78.0 (67.0, 84.0) | −0.673# | 0.501 |
| Males | 50 (61.0) | 26 (65.0) | 24 (57.1) | 0.532* | 0.466 |
| Hospital admission | |||||
| Medical ward | 28 (34.1) | 14 (35.0) | 14 (33.3) | 0.025* | 0.874 |
| Surgical ward | 54 (65.9) | 26 (65.0) | 28 (66.7) | ||
| Underlying conditions | |||||
| Diabetes | 27 (32.9) | 12 (30.0) | 15 (35.7) | 0.303* | 0.582 |
| Hypertension | 36 (43.9) | 14 (35.0) | 22 (52.4) | 2.513* | 0.113 |
| Chronic cardiac disease | 18 (22.0) | 7 (17.5) | 11 (26.2) | 0.903* | 0.342 |
| Chronic liver disease | 9 (11.0) | 5 (12.5) | 4 (9.5) | 0.006* | 0.938 |
| Solid tumor | 30 (36.6) | 15 (37.5) | 15 (35.7) | 0.028* | 0.867 |
| COPD | 2 (2.4) | 0 (0.0) | 2 (4.8) | -Δ | 0.494 |
| Hematological malignancy | 5 (6.1) | 2 (5.0) | 3 (7.1) | 0.000* | 1.000 |
| Chronic renal dysfunction | 17 (20.7) | 4 (10.0) | 13 (31.0) | 5.473* | 0.019 |
| Surgery | 48 (58.5) | 25 (62.5) | 23 (54.8) | 0.505* | 0.477 |
| GCS score | 11.0 (9.0, 15.0) | 11.0 (11.0, 15.0) | 10.0 (6.0, 11.0) | −4.225# | 0.000 |
| Previous treatment | |||||
| Antifungal treatment | 27 (32.9) | 12 (30.0) | 15 (35.7) | 0.303* | 0.582 |
| Caspofungin | 22 (26.8) | 11 (27.5) | 11 (26.2) | 0.018* | 0.894 |
| Fluconazole | 39 (47.6) | 19 (47.5) | 20 (47.6) | 0.000* | 0.991 |
| Amphotericin B | 2 (2.4) | 0 (0.0) | 2 (4.8) | -Δ | 0.494 |
| Voriconazole | 32 (39.0) | 18 (45.0) | 14 (33.3) | 1.172* | 0.279 |
| Previous steroid therapy | 25 (30.5) | 10 (25.0) | 15 (35.7) | 1.110* | 0.292 |
| Previous antibiotic therapy | 63 (76.8) | 31 (77.5) | 32 (76.2) | 0.020* | 0.888 |
| Laboratory data | |||||
| P/F ratio | 256.1 (188.4, 337.3) | 290.5 (241.5, 370.8) | 224.0 (130.0, 270.0) | −3.553# | 0.000 |
| Anemia (HGB < 70 g/l) | 27 (32.9) | 10 (25.0) | 17 (40.5) | 2.222* | 0.136 |
| Neutropenia (< 1 months) | 7 (8.5) | 2 (5.0) | 5 (11.9) | 0.523* | 0.470 |
| WBC > 20*109/l | 26 (31.7) | 11 (27.5) | 15 (35.7) | 0.638* | 0.424 |
| Temperature > 38 °C | 68 (82.9) | 31 (77.5) | 37 (88.1) | 1.624* | 0.202 |
| Hypoproteinemia | 81 (98.8) | 39 (97.5) | 42 (100.0) | -Δ | 0.488 |
| MAP, mean (SD) | 76.7 (66.5, 90.0) | 85.5 (73.3, 94.5) | 68.0 (57.0, 78.3) | −4.134# | 0.000 |
| Previous invasive procedures | |||||
| Central venous catheter | 13.0 (5.5, 27.0) | 13.0 (6.0, 25.5) | 14.0 (4.5, 29.5) | −0.454# | 0.650 |
| Urinary tract catheter | 13.0 (5.0, 27.0) | 12.5 (5.0, 24.0) | 17.0 (5.5, 35.5) | −1.026# | 0.305 |
| Total parenteral nutrition | 10.5 (3.8, 21.3) | 8.5 (3.3, 15.8) | 13.0 (4.5, 27) | −1.023# | 0.307 |
| Mechanical ventilation | 3.5 (1.0, 10.3) | 2.5 (1.0, 9.5) | 5.50 (1.0, 15.0) | −1.514# | 0.130 |
| SOFA score | 8.0 (4.0, 11.0) | 5.0 (4.0, 8.0) | 10.0 (8.5, 14.0) | −4.628# | 0.000 |
| Outcome (days) | |||||
| ICU length of stay | 16.0 (4.8, 51.8) | 16.0 (5.3, 36.3) | 14.5 (3.0, 66.0) | −0.223# | 0.823 |
| Hospital length of stay | 45.0 (27.8, 81.3) | 40.0 (28.0, 98.0) | 49.0 (26.5, 81.0) | −0.014# | 0.989 |
| Mechanical ventilation | 8.5 (1.8, 23.3) | 5.0 (1.0, 11.0) | 11.5 (3.0, 37.5) | −2.461# | 0.014 |
*: Chi-square test; #: rank sum test; Δ: Fisher’s exact test
P50 (P25,P75): the quartile summary is viewed as P25, P50, and P75. For P50, there is a 50% chance that the mean power production will not be reached at any given time