Fig. 6.

HIG2-silenced HepG2 and SMMC-7721 cells modulate the activity of NK cells through the STAT3 signaling pathway. a Phosphorylation levels of STAT1, STAT3, STAT4, and STAT5 in NK cells treated with the conditioned media of SMMC-7721 cells in the siR-HIG2 or siR-NC group, as determined by flow cytometry. *P<0.05 compared with the siR-NC group. b Expression of phosphorylated STAT3 protein in NK cells treated with the conditioned media of HepG2 or SMMC-7721 cells in the siR-HIG2 or siR-NC group, as determined by Western blotting. *P < 0.05 compared with siR-NC of the same cell type