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. 2019 Feb 13;67(6):385–400. doi: 10.1369/0022155419831641

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Figure 10. — CPE expression is similar in islet cells of control and T2D donors. Photomicrographs illustrate representative islets of controls (A) and T2D (B, C) donors immunostained for CPE (green) and insulin (red). Note that the expression of the enzyme is similar in controls and T2D groups. (C) illustrates an islet from a T2D sample with few beta cells and low CPE levels. Bar: 20 µm. (D) Histogram document that the total fluorescence of islets of control and T2D, measured as indicated in methods, is similar (10 islets/donor, 4 donors/group). Islets similar to that in C were not included in the calculation of the FI. Abbreviations: CPE, carboxypeptidase E; T2D, type 2 diabetes; FI, fluorescence intensity; a.u., arbitrary unit; NS, not significant.