Figure 4.

PC1/3 expression in islets with apparent beta cell loss. Photomicrograph A to D illustrates islets from donor control #6179 immunostained for insulin and PC1/3. Images in A and B illustrate islets displaying significant levels of both molecules; these islets were located near the islet illustrated in C, which contains a stained precipitate. Note that while islets in Fig. 4A and B contain regions devoid of beta cells, these areas lack a visible precipitate. Fig. D illustrates an islet “remnant” that was found in the same section of pancreas. Bar: 20 µm. Abbreviation: PC1/3, proprotein convertase 1/3.