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Comparative analysis of the PaLoc from C. difficile RT 017 and A + B + C. difficile strains. Arrows indicate open reading frames (ORFs) and the direction of transcription. The different enzymatic domain of the tcdB gene is responsible for the different CPE [48]. The nonsense mutation near the 5′ terminal of the tcdA gene is responsible for the loss of function of TcdA [49]. The 1.8 kb deletion near the 3′ terminal of the tcdA gene makes TcdA undetectable by many toxin EIAs [47].
