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. 2019 Jul;370(1):44–53. doi: 10.1124/jpet.118.255679

Fig. 1.

Fig. 1.

Mouse and human PXR agonists trigger IL-1β release from primed macrophages. (A) The rodent-specific PXR agonist PCN (10 and 100 μM for 6 hours) elicits significant IL-1β release from LPS-primed peritoneal mouse macrophages, as measured by enzyme-linked immunosorbent assay. Human-specific PXR agonists (B) SR121813 (SR 0.1, 1, 4, 10 μM; 6 hours) or (C) rifaximin (rifx 1, 5, 10, 100 μM; 6 hours) stimulated significant IL-1β release from wild-type PMA-differentiated THP-1 cells. N = 3 to 4; *P < 0.05 for indicated comparison generated by analysis of variance and Tukey’s post hoc test.