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. 2019 Jul;370(1):44–53. doi: 10.1124/jpet.118.255679

Fig. 6.

Fig. 6.

Blockade of pannexin-1 and inhibition of SFKs attenuates human PXR agonist-induced ATP and IL-1β release from PMA-differentiated THP-1 cells. (A) Selective inhibition of pannexin-1 with a pannexin-1 channel-blocking peptide (10Panx, 400 μM; or scrambled control peptide ScPanx) abolishes rifaximin (Rifx)- and SR12813 (SR)-induced ATP release from PMA-differentiated THP-1 cells. (B) Inhibition of SFKs with PP2 (10 μM) significantly reduces rifaximin (Rifx)- and SR12813- (SR)-induced ATP release from PMA-differentiated THP-1 cells. N = 4; *P < 0.05 for indicated comparison generated by analysis of variance and Tukey’s post hoc test.