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. Author manuscript; available in PMC: 2019 Jun 28.
Published in final edited form as: J Med Chem. 2018 Jun 19;61(12):5323–5331. doi: 10.1021/acs.jmedchem.8b00405

Figure 2. Optimization of peptide heterodimer.

Figure 2.

On confocal microscopy, fluorescence from binding of candidate heterodimer with linkers A) E2, B) Hex, C) E3, D) E6, and E) E10 to the surface (arrow) of SKBr3 cells can be seen. F) Quantified results show that the E3 linker provides the highest mean fluorescence intensity. P-values were determined using unpaired t-test. Measurements are an average of 10 randomly chosen cells from 4 images collected independently. G) Western blot shows EGFR and ErbB2 expression in SKBr3 and QhTERT cells.