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. Author manuscript; available in PMC: 2019 Jun 28.
Published in final edited form as: J Med Chem. 2018 Jun 19;61(12):5323–5331. doi: 10.1021/acs.jmedchem.8b00405

Figure 7. Specific binding of peptide heterodimer to Barrett’s neoplasia.

Figure 7.

On representative confocal microscopy images of human esophageal specimens ex vivo, QRH*-KSP*-E3-Cy5.5 (red) shows minimal staining to A) squamous (SQ) and B) Barrett’s esophagus (BE), and increased intensity with C) high-grade dysplasia (HGD) and D) esophageal adenocarcinoma (EAC). Similar results were found with AF568-labeled anti-EGFR antibody (yellow) and for AF488-labeled anti-ErbB2 antibody (green). Merged images show co-localization of peptide and antibody binding.