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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: Cell Rep. 2018 Oct 16;25(3):677–689.e4. doi: 10.1016/j.celrep.2018.09.058

Figure 2. Detection of βOHB as a Metabolite Altered by Dietary Salt.

Figure 2.

(A) PCA plots of data obtained from untargeted metabolomics analysis of plasma samples. Each sphere represents a single animal. Black spheres: low salt-fed group. Red spheres: high salt-fed group. Distinct clusters of black and red spheres indicate that the groups are dissimilar in their metabolomics profiles.

(B) Volcano plot of all detected metabolites by the untargeted GC-TOF-MS. Blue and red dots represent metabolites not significantly and significantly different between low and high salt-fed rats (p < 0.05, fold change [FC] >1.4). +, denotes βOHB.

(C) Plasma levels of βOHB.

(D) Confirmation of the decreased serum βOHB levels in fasting rats on a high salt diet. *p < 0.05, ns, not significant.