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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: Cell Rep. 2018 Oct 16;25(3):677–689.e4. doi: 10.1016/j.celrep.2018.09.058

Figure 3. Nutritional Intervention with βOHB Lowered Hypertension.

Figure 3.

Groups of 64- to 65-day-old S rats were administered with (n = 12) or without (n = 10) 20% v/v of 1,3-butanediol in drinking water for 5 weeks.

(A–D) Serum levels of βOHB on week 3 post administration of 1,3-butanediol (A), systolic (B), diastolic (C), and mean (D) arterial pressure data recorded by radio telemetry after 3 weeks on 1,3-butanediol. Data points are 4 hr moving averages. (E) Fasted and fed Na+/K+ ratio in serum on week 3 post administration of 1,3-butanediol.

(F and G) Microalbumin (F) and microalbumin/creatinine (G) ratio in serum on week 3 post administration of 1,3-butanediol. *p < 0.05, **p < 0.01, ***p < 0.001.