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. 2019 May 22;25:3804–3814. doi: 10.12659/MSM.915399

Figure 3.

Figure 3

DHA inhibits the IL-6/Stat3 pathway in OVA-induced asthmatic mice. (A) Protein expression of IL-6, total Stat3, and p-Stat3 (Tyr705) in lung tissues (n=5). (B) Relative band intensity of IL-6, T-Stat3, and p-Stat3 (Tyr705) in 3A. (C) Expression of inflammatory factors (il6, il10, tnf, il17a, il17f, il22) and transcription factor Stat3 in lung tissues were measured by qRT-PCR (n=7). (D) Cytokines in BALF (IFN-γ, IL-17F, IL-17A, IL-22, IL-10, Il-21, and GM-CSF) were measured by ELISA (n=7). * P<0.05, ** P<0.01, *** P<0.001. DHA – dihydroartemisinin; OVA – ovalbumin; qRT-PCR – quantitative real-time polymerase chain reaction; ELISA – enzyme-linked immunosorbent assay.