Table S2.

Profile of pertinent physical and laboratory parameters before and after roflumilast

Clinical category, units of measurement	Pre-roflumilast, Mean (SE)	Post-roflumilast, Mean (SE)	P-value
Common clinical examination parameters of interest
Body weight, kg	97.98 (4.8)	96.26 (5.2)	0.12
Systolic BP, mmHg	121 (3.7)	124 (3.2)	0.42
Diastolic BP, mmHg	71 (3.0)	72 (3.3)	0.92
Pulse, bpm	66 (3.7)	71 (4.1)	0.14*
Common clinical laboratory parameters of interest
Hemoglobin A1c, %	5.77 (0.13)	5.72 (0.09)	0.78
TSH, mcIU/mL	1.50 (0.27)	1.92 (0.65)	0.50
AST, U/L	19.88 (1.0)	17.75 (1.1)	0.05
ALT, U/L	21.5 (2.9)	19.88 (3.3)	0.38

Notes: N=8 for all variables except for TSH (n=7).

^*P-value as determined using Related Samples-Wilcoxon Signed Rank Test. All other p-values are from paired t-test analysis.

Abbreviations: ALT, Alanine Aminotransferase; AST, Aspartate Aminotransferase; bpm, beats per minute; TSH, thyroid stimulating hormone.