Table 1.

Variables determined from the hyper-insulinemic euglycemic clamp procedure

Variable, units of measurement	Total number of subjects	Pre-roflumilast, mean (SE)	Post-roflumilast, mean (SE)	P-value
Fasting plasma glucose, mg/dL	7	100.7 (3.4)	100.5 (2.7)	0.94*
Fasting plasma insulin, mcU/mL	6	20.6 (7.9)	27.3 (13.4)	0.46*
Basal hepatic glucose production, mg/kg lean mass/minute	7	2.45 (0.13)	2.78 (0.22)	0.10
Hepatic insulin resistance index	6	47.7 (15.7)	68.4 (27.7)	0.35*
Mean M value, mg/g fat free mass/minute	7	48.7 (10.4)	70.0 (20.1)	0.18*

Notes:

^*P-value as determined using Related Samples-Wilcoxon Signed Rank Test. All other P-values are from paired t-test analysis.