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. 2019 May 27;12:743–759. doi: 10.2147/DMSO.S182953

Table 2.

Fasting incretin hormones and mean AUC for mixed meal variables for eight subjects

Mixed meal variable Pre-roflumilast, mean (SE) Post-roflumilast, mean (SE) Mean percentage change P-value
Fasting GIP hormone, pg/mL 86.2 (11.3) 95.2 (14.2) 14.1% 0.32
Fasting GLP hormone, pg/mL 1.22 (0.28) 1.34 (0.31) 31.8% 0.76
Glucose AUC 20,977 (904) 21,193 (1143) +1.03% 0.78
C-peptide AUC 1,793 (341) 1,900 (411) +5.97% 0.48*
GIP hormone AUC 94,741 (9175) 94,819 (19620) +0.08% 0.99
GLP-1 hormone AUC 823 (137) 1,441 (410) +75.1% 0.18

Notes: Mean AUC for insulin was not assessed due to several hemolyzed samples that had to be excluded from the analysis.

*

P-value as determined using Related Samples-Wilcoxon Signed Rank Test. All other P-values are from paired t-test analysis.

Abbreviations: AUC, area under the curve; GIP, glucose-dependent Insulinotropic polypeptide or gastric inhibitory peptide; GLP, glucagon like peptide.