Table 2.
Fasting incretin hormones and mean AUC for mixed meal variables for eight subjects
| Mixed meal variable | Pre-roflumilast, mean (SE) | Post-roflumilast, mean (SE) | Mean percentage change | P-value |
|---|---|---|---|---|
| Fasting GIP hormone, pg/mL | 86.2 (11.3) | 95.2 (14.2) | 14.1% | 0.32 |
| Fasting GLP hormone, pg/mL | 1.22 (0.28) | 1.34 (0.31) | 31.8% | 0.76 |
| Glucose AUC | 20,977 (904) | 21,193 (1143) | +1.03% | 0.78 |
| C-peptide AUC | 1,793 (341) | 1,900 (411) | +5.97% | 0.48* |
| GIP hormone AUC | 94,741 (9175) | 94,819 (19620) | +0.08% | 0.99 |
| GLP-1 hormone AUC | 823 (137) | 1,441 (410) | +75.1% | 0.18 |
Notes: Mean AUC for insulin was not assessed due to several hemolyzed samples that had to be excluded from the analysis.
*
P-value as determined using Related Samples-Wilcoxon Signed Rank Test. All other P-values are from paired t-test analysis.
Abbreviations: AUC, area under the curve; GIP, glucose-dependent Insulinotropic polypeptide or gastric inhibitory peptide; GLP, glucagon like peptide.