Table 4.

Relative changes in lower extremity muscle fat by local fat compartment

Lower extremity muscle assessed	Mean % change in EMCL	Mean % change in IMCL	Mean % change in the muscle’s total lipid content
Soleus	+24%	−39%	−9.6%
Vastus Lateralis	+11%	−23%	−16%

Notes: Percentage changes was determined (difference between post-roflumilast and pre-roflumilast multiplied by 100% and then divided by pre-roflumilast value) for each subject and then averaged to obtain mean percentage changes.

Abbreviations: EMCL, extramyocellular lipid; IMCL, intramyocellular lipid.