Table 6.
Mean values of inflammatory and adhesion markers before and after roflumilast
| Inflammatory and adhesion markers | Pre-roflumilast, mean (SE) | Post-roflumilast, mean (SE) | P-value |
|---|---|---|---|
| TNF-α, pg/mL | 7.34 (1.1) | 7.50 (1.0) | 0.83* |
| MCP, pg/mL | 185.9 (23) | 162.2 (24) | 0.21* |
| Hs-CRP, mg/L | 2.5 (0.85) | 3.3 (0.73) | 0.42 |
| VCAM, ng/mL | 1,036 (393) | 1,065 (406) | 0.16* |
| ICAM, ng/mL | 439 (50) | 451 (55) | 0.57 |
| E-selectin, pg/mL | 28,551 (3195) | 30,247 (3686) | 0.40 |
| Adiponectin, ng/mL | 4,949 (542) | 4,468 (444) | 0.15 |
| Leptin, pg/mL | 28,957 (7142) | 25,763 (8141) | 0.20 |
Notes:
*
P-value as determined using Related Samples-Wilcoxon Signed Rank Test. All other P-values are from paired t-test analysis.
Abbreviations: HS CRP, high sensitivity C reactive protein; ICAM, intracellular adhesion molecule; MCP, monocyte chemoattractant protein; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.