Figure 5.

Correspondence of round-robin study-derived average log EC₅₀ values obtained for the 3 different cell viability measurements per test chemical with average logLC₅₀ values from fish acute toxicity testing. A, Correspondence of the cell line derived data with in vivo data obtained from the US EPA fathead minnow database (see Russom et al., 1997 and Tanneberger et al., 2013). B, Correspondence of the cell line derived data with the in vivo data for different fish species (SI Section 4.b). For Malathion (MAL), species for fish acute toxicity data are indicated: RT, rainbow trout (n = 19); BG, bluegill (n = 10); ZF, zebrafish (n = 3); GU, guppy (n = 1); CC, common carp (n = 12); JM, Japanese medaka (n = 1); FHM, fathead minnow (n = 3). All RTgill-W1 data are based on measured concentrations.