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. 2019 Mar 11;169(2):567–578. doi: 10.1093/toxsci/kfz070

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Anxiolytic effects of LEV therapy in DFP rats. EPM: Bar graph shows significantly lower time spent in the open-arm (A) and significantly higher closed-arm and less open-arm entries (B) by DFP rats indicative of anxiety-like condition and a significant anxiolytic effect of LEV therapy in DFP rats. LEV alone did not alter baseline EPM exploratory behavior while DFP+LEV rats were not significantly different than age-matched control rats. Bar graph shows no significant changes between total arm entries (C), distance moved (D), and velocity (E) between the age-matched control and DFP rats treated with saline or LEV. (Data expressed as mean ± SEM, *p < .05, 1-way ANOVA, Tukey’s test, n = 8 rats; *compared with CTL+SAL).