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. 2019 Mar 4;169(2):475–484. doi: 10.1093/toxsci/kfz059

Figure 2.

Figure 2.

In vivo effects of TBBPA on P-gp, BCRP, and MRP2 transport in male and female rat brain capillaries; VC—vehicle control, TBBPA—250 mg/kg by gavage. A, Male P-gp transport activity. B, Female P-gp transport activity. C, Male BCRP transport activity. D, Female BCRP transport activity. E, Male MRP2 transport activity. F, Female MRP2 transport activity. Each bar represents the mean value for 15–20 capillaries from a single preparation (pooled tissue from 5 to 7 rats, 15–20 weeks old); variability is shown as SE bars. Units are arbitrary fluorescence. Statistical comparisons: ***significantly different than control, p < .001. Abbreviations: BCRP, breast cancer resistant protein; MRP2, multidrug resistance-associated protein 2; P-gp, P-glycoprotein; TBBPA, tetrabromobisphenol A.