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. 2019 Mar 4;169(2):475–484. doi: 10.1093/toxsci/kfz059

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Published by Oxford University Press on behalf of the Society of Toxicology 2019.

This work is written by US Government employees and is in the public domain in the US

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Figure 4. — TBBPA dependent decreases in BCRP transport activity are dose- and time dependent. Dose dependent decreases at 4 h of TBBPA on (A) male and (B) female BCRP activity. (C) Male and (D) female BCRP transport activity exhibits time-dependent decreases from 100 nM TBBPA exposure. Shown are mean ± SEM for 15–20 capillaries from single preparation (pooled brains from 4 to 7 rats, 15–20 weeks old). ***p < .001, significantly different than control. Abbreviations: BCRP, breast cancer resistant protein; TBBPA, tetrabromobisphenol A.