Skip to main content
. 2019 Mar 4;169(2):475–484. doi: 10.1093/toxsci/kfz059

Figure 5.

Figure 5.

TBBPA induced P-gp transport requires transcription, translation and PPAR-γ. A, In males, pretreatment with an inhibitor of transcription, 1 μM actinomycin D (AMD), or translation, 1.8 mM cycloheximide (CHD), blocks TBBPA increases in P-gp activity. B, In males, co-treatment with 10 nM GW9662 and 100 nM TBBPA blocks P-gp induction. C, In females, co-treatment with 10 nM GW9662 and 100 nM TBBPA does not reverse TBBPA dependent decreases in P-gp induction. Shown are mean ± SEM for 10–20 capillaries from single preparation (pooled brains from 3 to 5 rats, 15–20 weeks old). ***p < .001, significantly different than control. Abbreviations: P-gp, P-glycoprotein; TBBPA, tetrabromobisphenol A.